

PRECIS-2 used as an implementation science tool for global environmental health
Randomized controlled trials (RCTs) that evaluate the efficacy of an intervention remain
underutilized in community-based environmental health research. RCTs that use a pragmatic
design emphasize the effectiveness of interventions in complex, real world settings.
Pragmatic trials may be especially relevant when community-based interventions address
social and environmental determinants that threaten health equity. The revised Pragmatic
Explanatory Continuum Indicator Summary (PRECIS-2) is a validated tool developed in
2015 by trialists to ensure that clinical trials are designed to fit their intended purpose, with
an assessment of applicability of the trial results to specific contexts. The purpose of this
cross-sectional study was to ask Ecolectivos study investigators and external implementation
scientists to evaluate the Ecolectivos study protocol using the PRECIS-2 tool prior to
the launch of the trial. Ecolectivos is an implementation science study, using a village-level
cluster randomized controlled trial design, to assess a behavioral intervention to reduce
household plastic waste burning in rural Guatemala.
1 Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, United States of America,
2 Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta,
GA, United States of America, 3 Center for Health Studies, Universidad del Valle de Guatemala, Guatemala
City, Guatemala, 4 Department of Environmental Sciences, Emory University, Atlanta, GA, United States of
America, 5 Department of Epidemiology and Biostatistics, University of California San Francisco, San
Francisco, CA, United States of America, 6 PRISE Center (Partnerships for Research in Implementation
Science for Equity), University of California San Francisco, San Francisco, CA, United States of America
‡ LMT and AF are co-first authors on this work.
* Lisa.thompson@emory.edu